|
Product name |
Evodiamine |
|
Other name |
EVODIAMINE10% PLANTEXTRACT;EVODIAMINE98%; EVODIAMINE20%PLANTEXTRACT; EVODIAMINE5%PLANTEXTRACT; Evodiaminestd ; EVODIAMINE; 8,13,13b,14-Tetrahydro-14-mChemicalbookethylindolo[2'3'-3,4]pyrido[2,1-b]quinazolin-5-[7H]-one; Indol(2',3':3,4)pyrido(2,1-b)quinazolin-5(7H)-one,8,13,13b,14-tetrahydro-14-methyl-,(S)- |
|
CAS No. |
518-17-2 |
|
Molecular formula |
C19H17N3O |
|
Molecular weight |
303.36 |
|
Purity |
98.0% |
|
Appearance |
Light yellow crystalline powder |
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Packing |
1kg/ pack |
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Application |
Pharmaceutical raw material |
Evodiamine is a quinolone alkaloid isolated from Evodia rutaecarpa. 1 Evodia Rutaecarpa is a very popular herb used in traditional Chinese medicine to treat a variety of ailments. Evodiamine has been shown to elicit a variety of biological effects including induction of apoptosis, inhibiting cancer cell proliferation, promoting cell cycle arrest in G2/M, inhibiting invasion and metastasis of cancer cells, inhibiting angiogenesis, induction of oxidative stress and subsequent apoptosis and inhibition of NF-κB.2 It also functions as an agonist of TRPV1 (EC50 = 1.03 μM) 3 and acts as an anti-inflammatory agent4.
1. Anti-inflammatory effect: Evodiamine has certain anti-inflammatory effect and has certain application value in the treatment of infectious diseases.
2. Role of reproductive system: Evodiamine can inhibit the synthesis of male hormones, which is helpful for the treatment of prostate cancer and other diseases.
3. Biotransformation: Evodiamine can be converted by bacteria in the gut into other compounds, which can play different roles.